What is Spravato®?
Spravato® (esketamine) is an FDA-approved nasal spray used with an oral antidepressant to treat adults with Treatment-Resistant Depression (TRD) or Major Depressive Disorder (MDD) with suicidal thoughts or actions.
How Does it Work?
Spravato® works differently from traditional antidepressants. It targets NMDA receptors in the brain and helps restore connections between nerve cells, which may relieve depressive symptoms more quickly—sometimes within hours to days.
What to Expect During Treatment
Administered in Office
You will use the nasal spray under supervision by a healthcare provider.
Observation
You’ll be monitored for at least 2 hours after each session for safety and comfort.
Frequency
Taken 1–2 times weekly and gradually decreased based on your treatment plan.
Safety & Monitoring
Before Each Treatment
Common Side Effects
These usually occur during or shortly after treatment and go away the same day:
• Dizziness or lightheadedness
• Nausea
• Feeling “disconnected” or “spacey”
• Drowsiness or fatigue
• Temporary increase in blood pressure
- Do not eat for 2 hours before your appointment.
- Do not drink liquids for 30 minutes before.
- Arrange for a responsible adult to drive you home — you cannot drive or operate machinery until the next day.
Benefits
Our Commitment at NewVision Healthcare Group
Compassionate, individualized care
Safe, monitored Spravato® sessions
Collaboration with your current psychiatric provider and therapist
Ongoing support and guidance throughout treatment
Rapid Relief
May relieve symptoms within hours to days.
Specialized Care
Helps patients who haven’t responded to traditional antidepressants.
Effective Results
Can reduce suicidal thoughts and depressive symptoms.